MANOJ KUMAR (SHELFORD)

Wednesday, September 3, 2014

Therapeutic efficacy of Cinnamomum tamala (Buch.-Ham.) and Aegle marmelos (L.) leaf

Sukumar Dandapat*, Manoj Kumar and M. P. Sinha

*Department of Zoology, Ranchi University, Ranchi, Jharkhand, India – 834008
*email: eaddress.sukumar27@gmail.com

Medicinal plants are widely used for therapy of various diseases and disorders due to presence of various bioactive phytochemicals. Among the studied phytochemicals polyphenol content was higher (16.7 ± 0.7 g/100g in C. tamala and 6.7 ± 0.61 g/100g in A. marmelos) and flavonoids content was lower in both plants (1.0 ± 1.01 g/100g and 0.9 ± 0.25 g/100g in C. tamala and A. marmelos respectively). Leaf extract of both plant were effective against S. aureus and P. mirabilis (6-10 mm ZOI and 100% inhibition at 0.25mg-5mg of leaf extracts in agar disk diffusion and broth dilution method respectively) and the leaf extract of both plant possess high antioxidant activity, 0.9% and 0.2% at 5μg/mL concentration 4% and 7% at 100 μg/mL concentration of A. marmelos and C. tamala leaf extracts respectively. Aqueous leaf extract of both the plants did not show cytotoxicity by haemolysis at 0.2 mg/mL-1mg/mL concentration.

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