Therapeutic efficacy of Cinnamomum tamala (Buch.-Ham.) and Aegle marmelos (L.) leaf

Sukumar Dandapat*, Manoj Kumar and M. P. Sinha

*Department of Zoology, Ranchi University, Ranchi, Jharkhand, India – 834008
*email: eaddress.sukumar27@gmail.com

Medicinal plants are widely used for therapy of various diseases and disorders due to presence of various bioactive phytochemicals. Among the studied phytochemicals polyphenol content was higher (16.7 ± 0.7 g/100g in C. tamala and 6.7 ± 0.61 g/100g in A. marmelos) and flavonoids content was lower in both plants (1.0 ± 1.01 g/100g and 0.9 ± 0.25 g/100g in C. tamala and A. marmelos respectively). Leaf extract of both plant were effective against S. aureus and P. mirabilis (6-10 mm ZOI and 100% inhibition at 0.25mg-5mg of leaf extracts in agar disk diffusion and broth dilution method respectively) and the leaf extract of both plant possess high antioxidant activity, 0.9% and 0.2% at 5μg/mL concentration 4% and 7% at 100 μg/mL concentration of A. marmelos and C. tamala leaf extracts respectively. Aqueous leaf extract of both the plants did not show cytotoxicity by haemolysis at 0.2 mg/mL-1mg/mL concentration.

Pharmacological Screening of Leaf Extract of Adhatoda vasica for Therapeutic Efficacy

Global Journal of Pharmacology 8(4): 494-500, 2014

ISSN 1992-0075

© IDOSI Publications, 2014

DOI: 10.5829/idosi.gjp.2014.8.4.8419

Pharmacological Screening of Leaf Extract of Adhatoda vasica for Therapeutic Efficacy

ManojKumar, Sukumar Dandapat, Amit Kumar and M.P. Sinha

Department of Zoology, RanchiUniversity, Ranchi-834008, Jharkhand, India

Abstract: In the present study Adhatoda vasica was screened for therapeutic efficacy. The plant leaf extract was screened for phytochemicals, mineral elements, antioxidant and reducing power activity, foaming and swelling index properties. Both qualitative and quantitative analyses of phytochemicals were done. The result showed the presence of alkaloids, tannins, saponins, phenolics and flavonoids. Tannins were maximum among all the detected phytochemicals (61.38 ± 0.8 mg/g). Phenolics were minimum (1.30 ± 0.1 mg/g). Following the presence of phytochemicals the plant leaf samples were also screened for antioxidant and reducing power ability. The screening for mineral elements revealed the presence of macro and micro elements. Potassium (K), Calcium (Ca), iron (Fe), Copper (Cu), Zinc (Zn), Chromium (Cr), Vanadium and Manganese (Mn) were detected in the leaf sample. Adhatoda vasica showed highest (68070 ± 35.58 ppm) concentration of Ca. V was lowest among all the mineral elements (118 ± 6.03 pm). Since the plant contains important phytochemicals, mineral elements, antioxidant and reducing power analysis, it may be good source of future medicines.

 

Key words: Phytochemicals,  Mineral Elements, Antioxidant, Reducing Power