PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENCY OF ADHATODA VASICA AND VITEX NEGUNDO

8(2): 727-730, 2013, The Bioscan (Supplement on Medicinal Plants)

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENCY OF ADHATODA VASICA AND VITEX NEGUNDO

Manoj Kumar*, Amit Kumar, Sukumar Dandapat, M. P. Sinha

*Corresponding author email: eaddress.manojkumar@gmail.com

ABSTRACT

The leaf samples of Adhatoda vasica and Vitex negundo were subjected to phytochemical analysis. Both the plants contained antioxidant phytochemicals such as alkaloids, tannin, saponins, phenolics and flavonoids; which were present in comparatively higher amount in Vitex negundo. Tannins were recorded highest among all the phytochemicals (93.9 ± 0.8 and 61.3 ± 0.8 mg/g in Vitex negundo and Adhatoda vasica respectively). Phenolics were recorded lowest (13. ± 0.1 and 8.1 ± 0.5 mg/g in Adhatoda vasica and Vitex negundo respectively.The methanolic extracts of the plants were also analyzed for antioxidant and reducing power potentiality. Both plants showed strong antioxidant and reducing power ability. The strong antioxidant and reducing power ability of the plant underlines their use as antioxidant supplement against diseases such as typhoid during which antioxidant system fails; cardiovascular diseases which are caused due to accumulation of Reactive oxygen species; ageing related diseases, Alzheimer, Prkinson’s disease, Amytrophic lateral sclerosis, cataractogenesis and other diseases.

KEY WORDS: antioxidant, Adhatoda vaisca, Vitex negundo

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Anti-typhoid Activity of Adhatoda vasica and Vitex negundo

Persian Gulf Crop Protection

Available online on: www.cropprotection.ir

ISSN: 2251-9343 (Online)

Volume 2 Issue 3, September 2013

Pages 64-75

Anti-typhoid Activity of Adhatoda vasica and Vitex negundo

Manoj Kumar1*, Sukumar Dandapat1, Amit Kumar1 and M. P. Sinha1

1-Department of Zoology, Ranchi University, Ranchi, India (*Corresponding author e-mail:eaddress.manojkumar@gmail.com).

Abstract: Typhoid activity is an acute systemic infection caused by Salmonella typhi. In present study

the methanolic leafs extract of Vitex negundo and Adhatoda vasica were analyzed for anti-typhoid

activity against Salmonella typhi. The leave sample was subjected to phytochemical analysis. The

concentration of all the phytochemicals studied was higher in Vitex negundo than Adhatoda vasica,

except alkaloids which was higher in Adhatoda vasica (11.3 ± 0.1mg/g) than Vitex negundo (8.6 ± 0.00

mg/g). Tannins were highest in both the plants, 61.3 ± 0.8 mg/g in Adhatoda vasica and 93.9 ± 0.8

mg/g in Adhatoda vasica. The antioxidant activity was determined and compared with BHA and

reducing power was compared with Ascorbic acid. Both the samples had high antioxidant and reducing

power activity. Several studies reported the loss of antioxidant system during infection of Salmonella

typhi. The leaf extracts of Adhatoda vasica and Vitex negundo showed considerable antioxidant activity

which can used as remedy against antioxidant system collapse and thus promises to be effective

antioxidant supplement for typhoid patients. Besides antioxidant activity the leaves of both plants

inhibited the growth of Salmonella typhi. The antibacterial activity of both leaf extracts were compared

with gentamycin. The results of present study shows that leaf extracts of Vitex negundo and Adhatoda vasica

confer anti-typhoid activity against Salmonella typhi.

Key Words: Anti-typhoid, Adhatoda vasica, Vitex negundo.